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* _“The Royal College of Psychiatrists, in 1998, **recommended delaying puberty** in young adolescents who experienced strong and persistent ‘cross-sex identification’ and distress around the physical body that intensifies with the onset of puberty.”_ * _“The Royal College of Psychiatrists, in 1998, **recommended delaying puberty** in young adolescents who experienced strong and persistent ‘cross-sex identification’ and distress around the physical body that intensifies with the onset of puberty.”_
* _“Puberty blockers are not ‘novel' treatment. They were **recommended by prominent bodies of medical opinion** in the UK and internationally over two decades ago, and have thus been part of standard medical treatment for many years.”_ * _“Puberty blockers are not ‘novel' treatment. They were **recommended by prominent bodies of medical opinion** in the UK and internationally over two decades ago, and have thus been part of standard medical treatment for many years.”_
* _“GnRHa has been used in the treatment of gender dysphoria **since the mid 1990s**, and their efficacy in delaying puberty in adolescents is documented by **numerous studies and scientific publications**” (21 scientific studies are then listed)_ * _“GnRHa has been used in the treatment of gender dysphoria **since the mid 1990s**, and their efficacy in delaying puberty in adolescents is documented by **numerous studies and scientific publications**” (21 scientific studies are then listed)_
* [Karalexi et al. 20](https://doi.org/10.1016/j.psyneuen.2020.104721)
* Study on the cognitive side-effects of puberty blockers
* _“Current evidence **does not support an adverse impact of gender-affirming hormone therapy on cognitive performance** in birth-assigned either male or female transgender individuals”_
* _“An enhanced effect on visuospatial ability following post-pubertal hormone therapy was shown in assigned females”_
* _“Pooling data from cross-sectional studies showed a higher performance in verbal working memory in treated assigned males”_
* [Endocrine Society Guidelines: Hebree et al 17](https://academic.oup.com/jcem/article/102/11/3869/4157558) * [Endocrine Society Guidelines: Hebree et al 17](https://academic.oup.com/jcem/article/102/11/3869/4157558)
* A clinical practice guideline for puberty blockers * A clinical practice guideline for puberty blockers
* _“Puberty suppression typically **relives distress for trans adolescents** by halting progression of physical changes such as breast growth in trans males and voice deepening in trans females and is reversible in its effects”_ * _“Puberty suppression typically **relives distress for trans adolescents** by halting progression of physical changes such as breast growth in trans males and voice deepening in trans females and is reversible in its effects”_